Reacción #2195525
ord-dd56e53c41784c72a1551f4281de238a
Ecuación de reacción
ethyl 1-{9-[(4S,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(cyclopentylamino)purin-2-yl}pyrazole-4-carboxylate
methylamine
→
(1-{9-[(4S,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(cyclopentylamino)purin-2-yl}pyrazol-4-yl)-N-methylcarboxamide
Reactantes
Reactivos
Ninguno
Disolventes
Condiciones de reacción
Temperatura
50°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.
Tratamiento posterior
- 1OtroThe solvent was then removed
- 2Otrothe residue purified
Procedimiento
70 mg of the ethyl 1-{9-[(4S,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(cyclopentylamino)purin-2-yl}pyrazole-4-carboxylate prepared in Example 3 was dissolved in 5 mL of 2M methylamine in methanol in a sealed tube. The mixture was stirred at 50° C. for 24 hours. The solvent was then removed and the residue purified using TLC with a 15:1 dichloromethane:methanol solution to yield (1-{9-[(4S,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(cyclopentylamino)purin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.