Reacción #2195490

Ecuación de reacción

2-Thiophenecarbonylchloride

tert-butyl-1-piperazinecarboxylate

→

solids

Rendimiento 88.1%

4-(Thiophene-2-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

Rendimiento 88.1%

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe precipitate was filtered
2. 2
   Lavadowashed several times with water
3. 3
   Otrodried

Procedimiento

2-Thiophenecarbonylchloride (2.04 g, 1.49 mL) was added to a solution of tert-butyl-1-piperazinecarboxylate (2.5 g, 13.4 mmol) and DMAP (20 mg) in pyridine (15 mL) at 0° C. under N2 atmosphere and stirred at room temperature for overnight. The mixture was poured into ice water, the precipitate was filtered, washed several times with water, and dried to yield white solids (3.5 g, 88%). Mp 76° C. 1H NMR (DMSO-d6): δ 1.42 (s, 12H), 3.40 (m, 4H), 3.61 (m, 4H), 7.12 (m, 1H), 7.43 (d, J=4.1 Hz, 1H), 7.77 (d, J=4.8 Hz, 1H). EIMS m/z 297 (M+1), 319 (M+23). Anal. (C14H20N2O3S) C, H, N.

Fuente