Reacción #2195473

ord-043dc0a2b807409b8a6633c7a76e8f91

Ecuación de reacción

Oc1ccccc1
phenol
[H-].[Na+]
sodium hydride
Cl
HCl
→
c1ccc2c(c1)oc1ccccc12
Dibenzofuran

Reactantes

Oc1ccccc1
phenol
[H-].[Na+]
sodium hydride
Cl
HCl

Reactivos

Ninguno

Disolventes

CS(C)=O
DMSO

Condiciones de reacción

Temperatura
120°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    ExtracciónThe aqueous phase is extracted with MTB ether
  2. 2
    SecadoThe organic phase is dried over sodium sulfate
  3. 3
    Otroevaporated
  4. 4
    Otrochromatographed on silica gel

Procedimiento

The phenol 10 is dissolved in DMSO under nitrogen, a 60% sodium hydride/mineral oil suspension is added, and the mixture is warmed to 120° C. After 5 hours at this temperature, the cooled batch is added to dil. HCl solution. The aqueous phase is extracted with MTB ether. The organic phase is dried over sodium sulfate, evaporated and chromatographed on silica gel.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07514127B2uspto-grants-2009_04