Reacción #219277

Ecuación de reacción

1,4-Dioxa-spiro[4.5]decan-8-one

2-Methyl-propane-2-sulfinic acid amide

NaHCO3

→

Compound 15

Rendimiento 45.8%

2-Methyl-propane-2-sulfinic acid (1,4-dioxa-spiro[4.5]dec-8-ylidene)-amide

Rendimiento 45.8%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroby flushing with N2(g) for 30 min
2. 2
   Filtraciónfollowed by filtration
3. 3
   Lavadoan EtOAc rinse
4. 4
   SecadoThe organic layer was dried with MgSO4
5. 5
   Filtraciónfiltered
6. 6
   Concentraciónconcentrated under reduced pressure

Procedimiento

An oven dried round-bottom flask was cooled to room temperature by flushing with N2(g) for 30 min. 1,4-Dioxa-spiro[4.5]decan-8-one (1.35 g, 8.66 mmol) (dissolved in 12 mL THF), 2-Methyl-propane-2-sulfinic acid amide (1.0 g, 8.25 mmol) (dissolved in THF), and titanium(IV) ethoxide (3.77 g, 16.50 mmol) were added. The reaction was stirred for 4 h at room temperature. To the mixture was added 15 mL saturated NaHCO3 followed by filtration and an EtOAc rinse. The organic layer was dried with MgSO4, filtered and concentrated under reduced pressure yielding 0.98 g of Compound 15.

Fuente