Reacción #2192102

Ecuación de reacción

1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(5-iodopentyloxy)phenyl]azetidin-2-one

6-methylaminohexane-1,2,3,4,5-pentaol

→

1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-{5-[methyl-(2,3,4,5,6-pentahydroxyhexyl)amino]pentyloxy}phenyl)azetidin-2-one

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónAfter concentration
2. 2
   Otroa rotary evaporator and oil pump vacuum at 40° C.
3. 3
   Otrothe residue is purified by preparative HPLC
4. 4
   OtroThe product is obtained as an oil

Procedimiento

170 mg of 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(5-iodopentyloxy)phenyl]azetidin-2-one are dissolved in 5 ml of absolute dimethylformamide. 220 mg of 6-methylaminohexane-1,2,3,4,5-pentaol are then added, and the reaction solution is stirred at 50° C. for 2 h. After concentration using a rotary evaporator and oil pump vacuum at 40° C., the residue is purified by preparative HPLC. The product is obtained as an oil. C36H46F2N2O8 (672) MS (ESI): M+

Fuente