Reacción #2191303

Ecuación de reacción

Trifluoroacetic acid

Boc aldehyde

tert-butyl (2-chloro-3-formylpyridin-4-yl)carbamate

dichloromethane

→

4-Amino-2-chloronicotinaldehyde

Disolventes

MTBE

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe temperature below 25° C
2. 2
   Temperaturacooled to room temperature
3. 3
   Filtraciónfiltered
4. 4
   Lavadothe filter cake rinsed with MTBE (10 mL×2)
5. 5
   SecadoSolid 1-5c TFA salt was dried under vacuum

Procedimiento

Trifluoroacetic acid (17.4 mL, 234 mmol) was added carefully to a stirred mixture of Boc aldehyde 1-4 (20 g, 78.1 mmol) and dichloromethane (60 mL) keeping the temperature below 25° C. The solution was warmed to 35° C., aged overnight (vigorous off-gassing) and then cooled to room temperature. 25 mL of MTBE was added and the resulting white slurry was aged for one hour, filtered, and the filter cake rinsed with MTBE (10 mL×2). Solid 1-5c TFA salt was dried under vacuum.

Fuente