Reacción #218655

Ecuación de reacción

(S)-2-[4-(6,7-difluoro-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-yl)-1-methyl-piperazin-2-yl]-ethanol

hydrogen chloride

→

title compound

Rendimiento 98.0%

(S)-2-[4-(6,7-Difluoro-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-yl)-1-methyl-piperazin-2-yl]-ethanol dihydrochloride

Rendimiento 98.0%

Disolventes

ethyl acetate

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónAfter 18 hours filter the precipitate under a nitrogen atmosphere
2. 2
   Lavadowash with ethyl acetate
3. 3
   Otrodry under vacuum

Procedimiento

Dissolve (S)-2-[4-(6,7-difluoro-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-yl)-1-methyl-piperazin-2-yl]-ethanol (171 mg, 0.44 mmol) in ethyl acetate. Add 3 equivlents of hydrogen chloride in ethanol. After 18 hours filter the precipitate under a nitrogen atmosphere, wash with ethyl acetate and dry under vacuum to give the title compound (198 mg, 98%): Mass Spectrum (LCMS) 393 (M+1); 391 (M−1).

Fuente