Reacción #2186196

Ecuación de reacción

1-(2-Fluoro-ethyl)-7-hydroxy-1,2,3,4-tetrahydro-quinoline-6-carbaldehyde

(6-chloro-imidazo[1,2-a]pyridin-2-yl)-acetic acid methyl ester

piperidine

→

desired product

Rendimiento 67.4%

3-(6-Chloro-imidazo[1,2-a]pyridin-2-yl)-8-(2-fluoro-ethyl)-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one

Rendimiento 67.4%

Disolventes

benzene

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxed for 18 h
2. 2
   Otroto reach room temperature
3. 3
   Filtraciónthe precipitate filtered
4. 4
   Lavadowashed with acetonitrile
5. 5
   Otrodried under high vacuum

Procedimiento

200 mg (0.896 mmol) 1-(2-Fluoro-ethyl)-7-hydroxy-1,2,3,4-tetrahydro-quinoline-6-carbaldehyde and 201 mg (1 eq.) (6-chloro-imidazo[1,2-a]pyridin-2-yl)-acetic acid methyl ester in 6 mL benzene and 3 mL acetonitrile are treated with 0.177 mL (2 eq.) piperidine and refluxed for 18 h. The reaction mixture is allowed to reach room temperature and the precipitate filtered, washed with acetonitrile and dried under high vacuum to yield 240 mg (67%) of desired product as a yellow powder.

Fuente