Reacción #217824

Ecuación de reacción

phenyl (7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)carbamate

3-iodoaniline

water

→

N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N′-(3-iodophenyl)urea

Rendimiento 47.0%

Disolventes

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooled to room temperature
2. 2
   Extracciónthe product was extracted with ethylacetate
3. 3
   LavadoThe organic layer was washed with water
4. 4
   Secadobrine, dried over Na2SO4
5. 5
   Filtraciónfiltered
6. 6
   Concentraciónconcentrated under reduced pressure

Procedimiento

Next, a mixture of phenyl (7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)carbamate (30.0 mg, 0.11 mmol) and 3-iodoaniline (25.5 mg, 0.12 mmol) in 0.2 mL of DMSO was heated at 100° C. for 16 hours. After cooled to room temperature, water was added and the product was extracted with ethylacetate. The organic layer was washed with water then brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to obtain N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-N′-(3-iodophenyl)urea (20.3 mg, 47% yield).

Fuente