Reacción #2175515

Ecuación de reacción

( 4 )

2-benzyloxycarbonylamino-4-(1-ethoxycarbonyl-2-hydroxy-ethylcarbamoyl)-butyric acid ethyl ester

→

( 5 )

Rendimiento 75.1%

2-amino-4-(1-ethoxycarbonyl-2-hydroxy-ethylcarbamoyl)-butyric acid ethyl ester

Rendimiento 75.1%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe catalyst was removed by filtration
2. 2
   Lavadothe solution was washed with ethanol
3. 3
   OtroThe solvent was removed in a rotary evaporator
4. 4
   OtroThe residue was dried in a vacuum oven (50° C.)

Procedimiento

A solution of (4) (11.4 g, 26.86 mmol) in ethanol (225 ml) containing 1.2 g 20% palladium on activated carbon (50% wet) was hydrogenated at 30 psi for 3 hrs. The catalyst was removed by filtration and the solution was washed with ethanol. The solvent was removed in a rotary evaporator. The residue was dried in a vacuum oven (50° C.) to produce (5) (5.86 g, 75%).

Fuente