Reacción #2175507

Ecuación de reacción

dimethyl malonate

H2SO4

dimethyl malonate

hexadecanol

ethylacetate hexane

→

dihexadecyl malonate

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was heated
2. 2
   Otrowas converted according to TLC (approximately 4 days)
3. 3
   Extracciónextracted with water (3 times)
4. 4
   Secadodried over MgSO4
5. 5
   OtroAn analytically pure sample was obtained by column chromatography on silica gel using

Procedimiento

H2SO4 (conc) (0.1 mL, 0.0036 mol % was slowly added to a mixture of dimethyl malonate (2 g, 0.015 mol) and hexadecanol (15 mL, 0.061 mol) and the mixture was heated at reflux until all dimethyl malonate was converted according to TLC (approximately 4 days). The product mixture was dissolved in dichloromethane (DCM), extracted with water (3 times) and dried over MgSO4. An analytically pure sample was obtained by column chromatography on silica gel using a 1:9 mixture of ethylacetate/hexane. Yield: 5.5 g (65.7%), see JP 57067510.

Fuente