Reacción #2175502

ord-c163a065aa9f44c9b5d9ab4a1a4a842d

Ecuación de reacción

COc1ccc(C(=O)N[C@@H]2CN3CCC2CC3)c(OC)c1
Compound 88S
COc1ccc(C(=O)N[C@@H]2CN3CCC2CC3)c(OC)c1
(S)-2,4-dimethoxy-N-(quinuclidin-3-yl)benzamide
COc1ccc(OC)c(C(=O)O)c1
2,5-dimethoxybenzoic acid
COc1ccc(OC)c(C(=O)N[C@@H]2CN3CCC2CC3)c1
Title compound
COc1ccc(OC)c(C(=O)N[C@@H]2CN3CCC2CC3)c1
(S)-2,5-dimethoxy-N-(quinuclidin-3-yl)benzamide

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Title compound was synthesized according to the procedure used in the synthesis of Compound 88S using 2,5-dimethoxybenzoic acid in place of 2,4-dimethoxybenzoic acid. 1H NMR (400 MHz, Acetone-D4) δ (ppm): 7.61 (m, J=4 Hz, 1H), 7.11 (s, 1H), 7.07 (m, J=4 Hz, 1H), 4.07 (m, 1H), 4.00 (s, 3H), 3.80 (s, 3H), 3.34 (s, 3H), 2.89-2.82 (m, 4H), 2.62 (m, 1H), 1.98 (m, 1H), 1.84 (m, 1H), 1.84 (m, 2H), 1.52 (m, 1H). C16H22N2O3=290.16 LCMS (M+H): m/z 291

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08435762B2uspto-grants-2013_05