Reacción #2175500
ord-46f61117ea4149e5bcc50cf12c77ec09
Ecuación de reacción
Compound 19S
(S)-2-methoxy-N-(quinuclidin-3-yl)benzamide
6-(trifluoromethyl)nicotinic acid
→
Title compound
(R)—N-(quinuclidin-3-yl)-6-(trifluoromethyl)pyridine-3-carboxamide
Reactivos
Ninguno
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
Title compound was synthesized according to the procedure used in the synthesis of Compound 19S, using 6-(trifluoromethyl)nicotinic acid in place of o-methoxybenzoic acid. 1H NMR (400 MHz, CDCl3) δ (ppm): 8.84 (s, 1H), 8.34 (dd, J=8 Hz, 1H), 8.23 (s, 1H), 8.12 (dd, J=8 Hz, 1H), 4.18 (m, 1H), 3.39 (ddd, J=10, 14 Hz, 1H), 2.95-2.87 (m, 4H), 2.67 (ddd, J=16 Hz, 1H), 2.06 (m, 1H), 1.79-1.74 (m, 3H), 1.50 (m, 1H). C14H16F3N3O=299.12 LCMS (M+H): m/z 300