Reacción #2175499

ord-2125a0946204422fb05df74e00bee6c7

Ecuación de reacción

COc1ccccc1C(=O)N[C@@H]1CN2CCC1CC2
Compound 19S
COc1ccccc1C(=O)N[C@@H]1CN2CCC1CC2
(S)-2-methoxy-N-(quinuclidin-3-yl)benzamide
O=C(O)c1ccc(C(F)(F)F)cn1
5-(trifluoromethyl)picolinic acid
O=C(N[C@H]1CN2CCC1CC2)c1ccc(C(F)(F)F)cn1
Title compound
O=C(N[C@H]1CN2CCC1CC2)c1ccc(C(F)(F)F)cn1
(R)—N-(quinuclidin-3-yl)-5-(trifluoromethyl)pyridine-2-carboxamide

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Title compound was synthesized according to the procedure used in the synthesis of Compound 19S, using 5-(trifluoromethyl)picolinic acid in place of o-methoxybenzoic acid. 1H NMR (400 MHz, CDCl3) δ (ppm): 8.98 (s, 1H), 8.22 (dd, J=8 Hz, 1H), 7.71 (d, J=8 Hz, 1H), 6.36 (s, 1H), 4.11 (m, 1H), 3.39 (dd, J=16 Hz, 1H), 2.83-2.77 (m, 4H), 2.56 (ddd, J=16 Hz, 1H), 2.00 (m, 1H), 1.66 (m, 3H), 1.50 (m, 1H). C14H16F3N3O=299.12 LCMS (M+H): m/z 300

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08435762B2uspto-grants-2013_05