Reacción #2171038

ord-fcb1c744209645f89d6f782b632aac37

Ecuación de reacción

CCC1CCC(C2CCC(c3cc(F)c(N(Cc4ccccc4)Cc4ccccc4)c(F)c3)CC2)CC1
dibenzyl[4-(4′-ethylbicyclohexyl-4-yl)-2,6-difluorophenyl]-amine
CCC1CCC(C2CCC(c3cc(F)c(N)c(F)c3)CC2)CC1
4-(4′-ethylbicyclohexyl-4-yl)-2,6-difluorophenylamine

Disolventes

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

40.8 g of dibenzyl[4-(4′-ethylbicyclohexyl-4-yl)-2,6-difluorophenyl]-amine are hydrogenated using 10 g of Pd/C/H2 (5%) in 400 ml of THF. Conventional work-up gives 4-(4′-ethylbicyclohexyl-4-yl)-2,6-difluorophenylamine.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06716491B2uspto-grants-2004_04