Reacción #2170875

Ecuación de reacción

3,4-dibenzyloxyphenacyl bromide

N-[2-(4-carbamoylmethylphenoxy)ethyl]benzylamine

sodium carbonate

→

N-benzyl-N-(3,4-dibenzyloxybenzoyl)methyl-2-(4-carbamoylmethylphenoxy)ethylamine

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 3 hours
2. 2
   Filtraciónfiltered hot
3. 3
   Otroto remove the inorganic sediment
4. 4
   Otroevaporated in vacuo
5. 5
   Otroto afford a thick syrup
6. 6
   OtroThe latter was crystallized upon trituration in diethyl ether
7. 7
   Otroa sample of the resultant solid was recrystallized from ethanol

Procedimiento

A mixture 3,4-dibenzyloxyphenacyl bromide (32.8 g.), N-[2-(4-carbamoylmethylphenoxy)ethyl]benzylamine (22.8 g.), anhydrous sodium carbonate (8.4 g.) and ethanol (1 liter) was boiled under reflux for 3 hours, then filtered hot to remove the inorganic sediment and evaporated in vacuo to afford a thick syrup. The latter was crystallized upon trituration in diethyl ether and a sample of the resultant solid was recrystallized from ethanol to give N-benzyl-N-(3,4-dibenzyloxybenzoyl)methyl-2-(4-carbamoylmethylphenoxy)ethylamine, m.p. 99°-101° C.

Fuente