Reacción #216907

ord-57fd1430ce8949a6a7d3214a55e2af97

Ecuación de reacción

O=Cc1cnc2ccccc2c1
Quinoline-3-carbaldehyde
N[C@@H](CS)C(=O)O
L-cysteine
O=C(O)C1CSC(c2cnc3ccccc3c2)N1
2-(3-quinolyl)thiazolidine-4-carboxylic acid
Rendimiento 75.0%

Reactivos

Ninguno

Disolventes

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe resultant crystalline precipitate was collected by suction
  2. 2
    Filtraciónfiltrating
  3. 3
    Lavadowashed with 50% ethanol
  4. 4
    Otrodried

Procedimiento

Quinoline-3-carbaldehyde (1.57 g) and 1.21 g of L-cysteine were dissolved in 50 ml of 50% ethanol, and the solution was stirred at room temperature for 1 hour. The resultant crystalline precipitate was collected by suction filtrating, washed with 50% ethanol and dried to give 1.95 g of 2-(3-quinolyl)thiazolidine-4-carboxylic acid. Melting point 173°-175° C. (decomposition).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05470851uspto-grants-1995_11