Reacción #216906

Ecuación de reacción

Pyridine-4-carbaldehyde

L-cysteine

charcoal

→

2-(4-pyridyl)-thiazolidine-4-carboxylic acid

Rendimiento 57.1%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas warm
2. 2
   FiltraciónThe mixture was filtered
3. 3
   TemperaturaAfter cooling
4. 4
   Filtraciónthe resultant crystalline precipitate was collected by filtration
5. 5
   Lavadowashed with ethanol

Procedimiento

Pyridine-4-carbaldehyde (1.07 g) and 1.21 g of L-cysteine were heated in 60% ethanol at a refluxing temperature for 4 hours. Activated charcoal (100 mg) was added to the reaction mixture while it was warm. The mixture was filtered. After cooling, the resultant crystalline precipitate was collected by filtration and washed with ethanol to give 1.2 g of 2-(4-pyridyl)-thiazolidine-4-carboxylic acid. Melting point 171°-173° C.

Fuente