Reacción #216647

Ecuación de reacción

methyl 4'-methyl-(1,1'biphenyl)-2-carboxylate

1-bromo-2,5-pyrrolidinedione

dibenzoyl peroxide

→

methyl 4'-(bromomethyl)[1,1'-biphenyl]-2-carboxylate

Rendimiento 100.0%

Disolventes

tetrachloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux temperature under a nitrogen atmosphere
2. 2
   Temperaturathe reaction mixture was cooled
3. 3
   Filtraciónfiltered
4. 4
   OtroThe filtrate was evaporated

Procedimiento

22.3 g of methyl 4'-methyl-(1,1'biphenyl)-2-carboxylate were dissolved in 900 ml of tetrachloromethane under a nitrogen flow. Then there were added 17.8 g of 1-bromo-2,5-pyrrolidinedione and a catalytic amount of dibenzoyl peroxide. After stirring for 2.5 hours at reflux temperature under a nitrogen atmosphere, the reaction mixture was cooled and filtered. The filtrate was evaporated, yielding >30 g (100% ) of methyl 4'-(bromomethyl)[1,1'-biphenyl]-2-carboxylate as a crude residue (interm. 44).

Fuente