Reacción #216539

Ecuación de reacción

Dodecanoyl chloride

2,4,6-triiodophenol

→

ester

Rendimiento 83.1%

2,4,6-Triiodophenyl dodecanoate

Rendimiento 83.1%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was heated under argon for 24 hrs
2. 2
   TemperaturaThe reaction mixture was cooled
3. 3
   Lavadowashed with saturated aqueous sodium bicarbonate
4. 4
   SecadoThe organic layer was dried over magnesium sulfate
5. 5
   Filtraciónfiltered
6. 6
   Otroevaporated to dryness under vacuum
7. 7
   Otroto give an off-white solid
8. 8
   OtroThe crude product was recrystallized from methanol

Procedimiento

Dodecanoyl chloride (2.95 ml, 12.8 mmol) was added to a suspension of 2,4,6-triiodophenol (6.0 g, 12.7 mmol) in refluxing acetonitrile (50 ml) and the mixture was heated under argon for 24 hrs. The reaction mixture was cooled and washed with saturated aqueous sodium bicarbonate. The organic layer was dried over magnesium sulfate, filtered, and evaporated to dryness under vacuum to give an off-white solid. The crude product was recrystallized from methanol to give 6.9 g (83%) of the desired ester, mp 68°-69° C.

Fuente