Reacción #216445

Ecuación de reacción

Boron trifluoride etherate

(3-propyloxetan-3-yl)methyl hex-5-ynoate

Triethylamine

→

1-(Pent-4-ynyl)-4-propyl-2,6,7-trioxabicyclo[2.2.2]octane

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solvent was removed in vacuo
2. 2
   OtroThe residue was partitioned between diethyl ether and water
3. 3
   OtroThe organic phase was separated
4. 4
   Lavadofurther washed with water and brine
5. 5
   Secadobefore drying over anhydrous magnesium sulphate
6. 6
   OtroThe solvent was evaporated in vacuo
7. 7
   Otrothe residue was purified by column chromatography on alumina eluting with 1:6 dichloromethane

Procedimiento

Boron trifluoride etherate (0.18 ml) was added to a stirred solution of (3-propyloxetan-3-yl)methyl hex-5-ynoate (1.33 g.) in dry dichloromethane (25 ml) at -70°. The mixture was allowed to warm to room temperature over 16 hours. Triethylamine (0.28 ml) was then added and the solvent was removed in vacuo. The residue was partitioned between diethyl ether and water. The organic phase was separated and further washed with water and brine before drying over anhydrous magnesium sulphate. The solvent was evaporated in vacuo and the residue was purified by column chromatography on alumina eluting with 1:6 dichloromethane:hexane saturated with ammonia. 1-(Pent-4-ynyl)-4-propyl-2,6,7-trioxabicyclo[2.2.2]octane was obtained as a colourless oil which crystallised on trituration (0.64 g) with hexane.

Fuente