Reacción #2164031
ord-ff6d08e03423427b8ae5a5c5373095af
Ecuación de reacción
4-chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine
piperidine
→
5-fluoro-4-piperidino-6-(2-pentynyloxy)pyrimidine
Rendimiento 97.8%
Reactivos
Ninguno
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
0.2 g of 4-chloro-5-fluoro-6-(2-pentynyloxy)pyrimidine and 0.24 g of piperidine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.24 g of 5-fluoro-4-piperidino-6-(2-pentynyloxy)pyrimidine (hereinafter, referred to as Compound (12)).