Reacción #2161258

Ecuación de reacción

1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine

hydrogen chloride

→

1-(5-Methylpyridin-2-yl)piperazine

Disolventes

dioxane

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe mixture is then concentrated
2. 2
   Extracciónextracted several times with dichloromethane
3. 3
   SecadoThe combined organic phases are dried over sodium sulfate
4. 4
   Concentraciónconcentrated
5. 5
   Otrodried in vacuo

Procedimiento

3.47 g (12.5 mmol) of 1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine are dissolved in 10 ml of dioxane, and 31 ml (125 mmol) of hydrogen chloride in dioxane (4 molar) are added. The mixture is stirred at RT for 2 h. The mixture is then concentrated and the residue is rendered alkaline using a 1M aqueous sodium hydroxide solution and extracted several times with dichloromethane. The combined organic phases are dried over sodium sulfate, concentrated and dried in vacuo.

Fuente