Reacción #2161256

Ecuación de reacción

ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

sodium hydroxide

hydrochloric acid

→

1-Methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylic acid

Disolventes

ethanol

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe solution is extracted with dichloromethane
2. 2
   ConcentraciónThe organic phase is concentrated in vacuo
3. 3
   OtroThe residue is purified by preparative HPLC

Procedimiento

835 mg (2.13 mmol) of ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate are suspended in 5 ml of ethanol and 12 ml of tetrahydrofuran. With ice cooling, 2 ml (25 mmol) of a 50% aqueous sodium hydroxide solution are added. The reaction mixture is stirred at room temperature overnight and then, with ice cooling, acidified with 1N hydrochloric acid. The solution is extracted with dichloromethane. The organic phase is concentrated in vacuo. The residue is purified by preparative HPLC.

Fuente