Reacción #2161255

Ecuación de reacción

4-(trifluoromethoxy)phenyl isocyanate

ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrosynthesis in analogy to Example 4A step 3
2. 2
   FiltraciónThe reaction mixture is filtered
3. 3
   Concentraciónthe filtrate is concentrated in vacuo
4. 4
   Otropurified chromatographically

Procedimiento

Under argon, 1.46 g (7.21 mmol) of 4-(trifluoromethoxy)phenyl isocyanate are added to 1.22 g (3.61 mmol) of ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (synthesis in analogy to Example 4A step 3, or also according to Tetrahedron Lett. 2003, 44, 1607 and the literature cited therein) in 50 ml of THF, and the mixture is stirred at room temperature overnight. The reaction mixture is filtered and the filtrate is concentrated in vacuo and purified chromatographically.

Fuente