Reacción #2161253

Ecuación de reacción

cyclohexane ethyl acetate

potassium carbonate

iodomethane

ethyl 4-nitro-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Filtraciónthe mixture is filtered
3. 3
   Lavadothe residue is washed with dichloromethane
4. 4
   OtroThe solid obtained
5. 5
   Otrois dried in vacuo

Procedimiento

6.80 g (36.7 mmol) of ethyl 4-nitro-1H-imidazole-2-carboxylate are dissolved in 140 ml of acetone, and 11.2 g (80.8 mmol) of potassium carbonate and 4.57 ml (73.5 mmol) of iodomethane are added. The mixture is then stirred at 60° C. for 4 h. According to TLC (cyclohexane/ethyl acetate 2:1), the starting material has been converted completely. After cooling, the mixture is filtered, the residue is washed with dichloromethane and the filtrate is freed from the solvent. The solid obtained is dried in vacuo.

Fuente