Reacción #2161251

Ecuación de reacción

ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate

hydrogen

→

Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe catalyst is filtered off
2. 2
   Concentraciónthe filtrate is concentrated in vacuo
3. 3
   OtroThe concentration residue is directly used further for the next reaction

Procedimiento

3.89 g (16.26 mmol) of ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate are dissolved in 50 ml of THF, and a spatula tip of Raney nickel is added. In a hydrogenation apparatus, the reaction mixture is hydrogenated with hydrogen at room temperature. The catalyst is filtered off and the filtrate is concentrated in vacuo. The concentration residue is directly used further for the next reaction.

Fuente