Reacción #2161248

Ecuación de reacción

ammonium formate

ethyl 1-benzyl-1H-imidazole-2-carboxylate

ammonium formate

→

Ethyl imidazole-2-carboxylate

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture is heated
2. 2
   Temperaturaunder reflux for about 6 h
3. 3
   TemperaturaAfter cooling
4. 4
   Filtraciónthe catalyst is filtered off
5. 5
   Concentraciónthe filtrate is concentrated in vacuo
6. 6
   OtroThe product that crystallizes out during this operation
7. 7
   Otrois triturated with 80 ml of ice-water
8. 8
   Filtracióncollected by suction filtration

Procedimiento

34.7 g (150.9 mmol) of ethyl 1-benzyl-1H-imidazole-2-carboxylate are dissolved in 1005 ml of ethanol, and 34 g of ammonium formate are added. The reaction mixture is heated under reflux for about 6 h. A total of 8 g of 10% palladium-on-carbon and 18 g of ammonium formate are thereby added in small portions. After cooling, the catalyst is filtered off and the filtrate is concentrated in vacuo. The product that crystallizes out during this operation is triturated with 80 ml of ice-water and collected by suction filtration.

Fuente