Reacción #215876

Ecuación de reacción

sodium hydride

4-(2,4-dichlorophenyl)-5-methyl-2-[N-(α-methylbenzyl)amino]thiazole

Compound 15

2-bromo-1-(2,4-dichlorophenyl)-1-propanone

→

4-(2,4-dichlorophenyl)-5-methyl-2-[N-(α-methylbenzyl)-N-(cyclopropylmethyl)amino]thiazole

Disolventes

cyclopropylmethyl bromide

methylene chloride

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroLeave for eight hours
2. 2
   Temperaturaunder reflux
3. 3
   Temperaturacool
4. 4
   workup.ADDITIONpour it onto ice

Procedimiento

At 0° C., add 0.5 g of 4-(2,4-dichlorophenyl)-5-methyl-2-[N-(α-methylbenzyl)amino]thiazole (prepared from Compound 92 and Compound 15 according to the process described in Example 1), dissolved in 5 ml of anhydrous tetrahydrofuran, and 66 mg of sodium hydride. After 30 minutes of stirring at room temperature, run in 0.67 ml of cyclopropylmethyl bromide dropwise. Leave for eight hours under reflux, cool and dilute the reaction medium with methylene chloride, then pour it onto ice.

Fuente