Reacción #215676

Ecuación de reacción

4-(benzyloxy)phenol

potassium methoxide

4-(trifluoromethoxy)-2-nitro-1-chlorobenzene

→

4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONTo a mixture of 10.01 g
2. 2
   TemperaturaThe mixture is heated
3. 3
   Otrothe reaction
4. 4
   OtroMost of the solvent is removed at reduced pressure
5. 5
   workup.ADDITIONthe residue treated with methylene chloride and water
6. 6
   LavadoThe methylene chloride solution is washed with saturated brine
7. 7
   Otrodried
8. 8
   Otrothe solvent removed

Procedimiento

To a mixture of 10.01 g. of 4-(benzyloxy)phenol and 3.51 g. (0.05 mole) of potassium methoxide in 75 ml. of DMF is added 12.08 g. (0.05 mole) of 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene. The mixture is heated to complete the reaction. Most of the solvent is removed at reduced pressure and the residue treated with methylene chloride and water. The methylene chloride solution is washed with saturated brine, dried, and the solvent removed, leaving 4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether.

Fuente