Reacción #215439

Ecuación de reacción

2-chlorocarbonyl-benzo[b]thiophene-3-sulfonic acid chloride

methanol

→

2-methoxycarbonyl-benzo[b]-thiophene-3-sulfonic acid chloride

Rendimiento 53.5%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxed for 3 hours
2. 2
   OtroThe reaction mixture was evaporated in vacuo
3. 3
   Otrothe residue was recrystallized twice from a little methanol

Procedimiento

168.0 gm (0.569 mol) of 2-chlorocarbonyl-benzo[b]thiophene-3-sulfonic acid chloride were dissolved in 1 liter of anhydrous chloroform, and the solution was admixed with 27.5 gm (0.858 mol) of dry methanol and refluxed for 3 hours. The reaction mixture was evaporated in vacuo, and the residue was recrystallized twice from a little methanol, yielding 88.5 gm (53.5% of theory) of colorless 2-methoxycarbonyl-benzo[b]-thiophene-3-sulfonic acid chloride. M.p.: 100°-101° C.

Fuente