Reacción #215410

Ecuación de reacción

m-phenoxybenzyl cyanide

butyl chloride

sodium hydroxide

→

pure product

Rendimiento 54.8%

2-(3-Phenoxyphenyl)hexanenitrile

Rendimiento 54.8%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture is heated at 90° for three hours
2. 2
   Extracciónextracted with hexane
3. 3
   LavadoThe combined hexane extracts are washed with water
4. 4
   Secadodried over MgSO4
5. 5
   OtroSolvent is evaporated
6. 6
   Otroto give 39 g of crude product
7. 7
   workup.DISTILLATIONVacuum distillation (149°-155°/0.2 mm)

Procedimiento

Into a three-necked 500 ml round-bottom flask are charged 35 g (0.17 mole) of m-phenoxybenzyl cyanide, 16.3 g (0.17 mole) of butyl chloride 4 g of tetraethylammonium bromide. To this mixture is added 27 g (0.34 mole) of 50% sodium hydroxide solution dropwise with stirring. The reaction mixture is heated at 90° for three hours. It is then poured into water and extracted with hexane. The combined hexane extracts are washed with water and dried over MgSO4. Solvent is evaporated to give 39 g of crude product. Vacuum distillation (149°-155°/0.2 mm) provides 24.7 g of pure product.

Fuente