Reacción #215405

Ecuación de reacción

sodium hydroxide

2-(2-phenoxyphenyl)hexanenitrile

dibromomethane

dimethyl sulfoxide

→

product

Rendimiento 82.3%

2-Cyano-2-(2-phenoxyphenyl)hexyl bromide

Rendimiento 82.3%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroReaction mixture
2. 2
   Temperaturais heated
3. 3
   Otroto give 60° for two hours
4. 4
   Extracciónextracted with hexane
5. 5
   LavadoCombined hexane extracts are washed with water
6. 6
   Secadodried over MgSO4
7. 7
   OtroSolvent is evaporated under vacuum

Procedimiento

Into a three-necked 300 ml round bottom flask are charged 10 g (0.038 mole) of 2-(2-phenoxyphenyl)hexanenitrile, 6.6 g (0.038 mole) of dibromomethane and 50 ml of dimethyl sulfoxide. To this mixture with stirring is added 3.2 g (0.04 mole) of 50% sodium hydroxide solution dropwise. Reaction mixture is heated to give 60° for two hours and then poured into water and extracted with hexane. Combined hexane extracts are washed with water and dried over MgSO4. Solvent is evaporated under vacuum to give 11.2 g of product.

Fuente