Reacción #215344

Ecuación de reacción

water

2,4-Dichloro-5-methyl-1,1,1-trifluorohex-2-ene

lithium chloride

→

2-chloro-5-methyl-1,1,1-trifluorohexa-2,4-diene

Rendimiento 76.0%

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with dichloromethane
2. 2
   Secadothe extracts dried over anhydrous sodium sulphate
3. 3
   workup.DISTILLATIONdistilled

Procedimiento

2,4-Dichloro-5-methyl-1,1,1-trifluorohex-2-ene (22.1 g) in dimethylformamide (100 ml) containing lithium chloride (5.0 g) is heated under a nitrogen atmosphere in an oil bath at 160° C. for 1.5 hours. The cooled mixture is added to water (1.5 l), extracted with dichloromethane and the extracts dried over anhydrous sodium sulphate and distilled to afford 2-chloro-5-methyl-1,1,1-trifluorohexa-2,4-diene (76%). The identity of the product was proved by comparison to 'Hnmr and infra-red spectra with those of authentic material.

Fuente