Reacción #214478

Ecuación de reacción

L-Cysteine

2-methyl-2-(methylthio)propanoyl chloride

hydrochloric acid

→

titled compound

Rendimiento 89.8%

N-[2-Methyl-2-(methylthio)propanoyl]-L-cysteine

Rendimiento 89.8%

Disolventes

potassium carbonate

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGthe mixture is stirred overnight at room temperature
3. 3
   Otrothe obtained crystals are separated by filtration
4. 4
   Otrodried

Procedimiento

L-Cysteine (7.1 g) is dissolved in 88 ml of 2 M potassium carbonate and 7.5 g of 2-methyl-2-(methylthio)propanoyl chloride [b.p. 78° C. (37 mmHg)] is added dropwise while stirring under a nitrogen atmosphere at 0° C. After the addition, the mixture is stirred overnight at room temperature. The mixture is acidified with hydrochloric acid and the obtained crystals are separated by filtration and dried to yield 10.4 g (89.8%) of the titled compound.

Fuente