Reacción #214431

ord-4c3209023b76405cace4f52bfb4581c5

Ecuación de reacción

CCCCCCCCCCCCCCCCOCC(O)CN1CCNCC1
1-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine
FC(F)(F)c1cccc(CCl)c1
3-(trifluoromethyl)benzyl chloride
→
CCCCCCCCCCCCCCCCOCC(O)CN1CCN(Cc2cccc(C(F)(F)F)c2)CC1
1-(3-trifluoromethylbenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)piperazine

Reactantes

CCCCCCCCCCCCCCCCOCC(O)CN1CCNCC1
1-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine
FC(F)(F)c1cccc(CCl)c1
3-(trifluoromethyl)benzyl chloride

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Following the procedure of Example 5, 1-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine was reacted with 3-(trifluoromethyl)benzyl chloride to form 1-(3-trifluoromethylbenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)piperazine, mp 133°-135° C.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04255426uspto-grants-1981_03