Reacción #214283

Ecuación de reacción

thiourea

sodium bicarbonate

3-carbamoyloxymethyl-7-(3-oxo-4-bromobutyramido)-3-cephem-4-carboxylic acid

→

3-carbamoyloxymethyl-7-(2-aminothiazol-4-yl)acetamido-3-cephem-4-carboxylic acid

Rendimiento 92.1%

Disolventes

tetrahydrofuran

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe resulting solution was stirred for 40 minutes at room temperature
2. 2
   OtroAfter the reaction
3. 3
   Filtraciónthe precipitated crystals were collected by filtration with suction
4. 4
   Lavadowashed with water, tetrahydrofuran and water in turn
5. 5
   Secadodried over phosphorus pentoxide

Procedimiento

To a solution of thiourea (0.103 g.) and sodium bicarbonate (0.11 g.) in a mixture of tetrahydrofuran (1.3 ml.) and water (1.3 ml.) was gradually added 3-carbamoyloxymethyl-7-(3-oxo-4-bromobutyramido)-3-cephem-4-carboxylic acid (0.55 g.) with stirring at room temperature, and then the resulting solution was stirred for 40 minutes at room temperature. After the reaction, the precipitated crystals were collected by filtration with suction, washed with water, tetrahydrofuran and water in turn, and then dried over phosphorus pentoxide to give 3-carbamoyloxymethyl-7-(2-aminothiazol-4-yl)acetamido-3-cephem-4-carboxylic acid (0.48 g.).

Fuente