Reacción #2139924

Ecuación de reacción

fluorenone

2-bromobiphenyl

→

9.9′-Spirobifluorene

Rendimiento 80.0%

Disolventes

ether

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturarefluxed
3. 3
   FiltraciónThe produced yellow precipitate was filtered
4. 4
   workup.STIRRINGstirred in cold ammonium chloride
5. 5
   Filtraciónthe obtained crystal was filtered again
6. 6
   Otrodried
7. 7
   workup.ADDITIONThereafter, acetic acid was added to the solid product
8. 8
   Temperaturathe solution was refluxed
9. 9
   workup.STIRRINGwhile stirring
10. 10
    workup.ADDITIONA small amount of hydrochloric acid was added
11. 11
    Otroto obtain the solid target compound
12. 12
    FiltraciónThe solid target compound was filtered
13. 13
    Lavadowashed
14. 14
    Otroto obtain pure target compound with the yield of 80%

Procedimiento

As shown in the following reaction 1, 6.1 g of 2-bromobiphenyl and 0.585 g of dried Mg were dissolved with ether, and 4.2 g of fluorenone dissolved in ether was added thereto, and refluxed while stirring overnight. The produced yellow precipitate was filtered, and stirred in cold ammonium chloride, and then the obtained crystal was filtered again and dried. Thereafter, acetic acid was added to the solid product, and the solution was refluxed while stirring. A small amount of hydrochloric acid was added thereto to obtain the solid target compound. The solid target compound was filtered and washed to obtain pure target compound with the yield of 80%.

Fuente