Reacción #2139287

Ecuación de reacción

water

nitric acid

Ethyl 6-chloro-4,N,N-trimethylanthranilate

compound 1

Ethyl 6-chloro-4,N,N-trimethylanthranilate

→

ethyl 6-chloro-4,N,N-trimethyl-5-nitroanthranilate

Disolventes

sulphuric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe yellow product was extracted into chloroform
2. 2
   Otrothe extracts were dried by filtration
3. 3
   Lavadoafter washing with water
4. 4
   OtroThe solvent was removed
5. 5
   Otrothe residue crystallised from ethanol

Procedimiento

Ethyl 6-chloro-4,N,N-trimethylanthranilate (compound 1) (3 g) was added dropwise with stirring to a solution of nitric acid (SG 1.43) (3 ml) in conc sulphuric acid (10 ml) at room temperature. The mixture was stirred overnight at room temperature, then poured into water (200 ml). The yellow product was extracted into chloroform, and the extracts were dried by filtration after washing with water. The solvent was removed and the residue crystallised from ethanol to give ethyl 6-chloro-4,N,N-trimethyl-5-nitroanthranilate (2 g) as yellow needles, mp 76° C.

Fuente