Reacción #2122538

Ecuación de reacción

TFA

TFA

1b

imidazole

1b

imidazole

1c

boronate

→

Biphenyl

Disolventes

MeOH

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrotime=3 min, Flow rate=4 ml/min, Wavelength=220 nm, LC/MS (M+H)+=625.32

Procedimiento

Example 1-4-d was prepared from 1-4-c and 1b in similar fashion to the preparation of 1d from 1b and 1c. 1H NMR (500 MHz, DMSO-d6) δ ppm 0.99-1.60 (m, 18 H) 1.75-2.11 (m, J=73.24 Hz, 6 H) 2.12-2.32 (m, 2 H) 3.32-3.41 (m, 2 H) 3.56 (s, 2 H) 4.63-5.02 (m, 2 H) 6.98-8.28 (m, 10 H) 11.67-12.33 (m, 2H); LC conditions: Phenomenex Luna 3.0×5.0 mm S10, Solvent A—0.1% TFA in 10% MeOH/90% H2O, Solvent B—0.1% TFA in 90% MeOH/10% H2O, 0 to 100% B over 2 min, Stop time=3 min, Flow rate=4 ml/min, Wavelength=220 nm, LC/MS (M+H)+=625.32. Retention time=1.438 min Additional Biphenyl Analogs were Prepared Similarly.

Fuente