Reacción #2119

Ecuación de reacción

diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate

ethyl iodide

potassium carbonate

→

Diethyl [4-(7-ethyl-3-methylxanthin-1-yl)butyl]phosphonate

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe solid was filtered off
2. 2
   Concentraciónthe filtrate was concentrated under reduced pressure
3. 3
   Filtraciónfiltered again
4. 4
   Otrocrystallized from diisopropyl ether

Procedimiento

7.2 g (0.02 mol) of diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate were suspended in 100 ml of DMF, treated with 4.7 g (0.03 mol) of ethyl iodide and 4.1 g (0.03 mol) of activated potassium carbonate and heated at 60° C. for 4 hours. The solid was filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

Fuente