Reacción #2116

Ecuación de reacción

benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate

ammonia

→

Monoethyl ammonium [4-(7-ethoxymethyl-3-methylxanthin-1-yl)butyl]-phosphonate

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe catalyst was filtered off
2. 2
   Concentraciónthe filtrate was concentrated under reduced pressure
3. 3
   Otrothe solution obtained
4. 4
   Otroafter evaporating the solvent
5. 5
   Otrowas then crystallized from diisopropyl ether

Procedimiento

6.3 g (0.013 mol) of benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate were hydrogenated in 100 ml of ethanol over 0.5 g of palladium (10%) on active carbon at room temperature in the course of 4 hours. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, the solution obtained was treated with methanolic ammonia and the residue which remained after evaporating the solvent was then crystallized from diisopropyl ether.

Fuente