Reacción #2109

Ecuación de reacción

diethyl 5-hydroxypentylphosphonate

3,4-dihydropyran

pyridinium toluene-4-sulfonate

→

Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 16 hours
2. 2
   LavadoThe solution was washed with water and saturated sodium hydrogen carbonate solution
3. 3
   Secadodried over sodium sulfate
4. 4
   workup.DISTILLATIONdistilled in a bulb tube

Procedimiento

A solution of 66.9 g (0.298 mol) of diethyl 5-hydroxypentylphosphonate, 32.6 g (0.38 mol) of 3,4-dihydropyran and 1 g (0.004 mol) of pyridinium toluene-4-sulfonate in 800 ml of dichloromethane was heated under reflux for 16 hours. The solution was washed with water and saturated sodium hydrogen carbonate solution, dried over sodium sulfate and distilled in a bulb tube.

Fuente