Reacción #2091

Ecuación de reacción

benzyl chloride

sodium hydride

3-methylxanthine

hydrogen

→

7-Benzyl-3-methylxanthine

Disolventes

water

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated at 120° C. for a further 6 hours
2. 2
   TemperaturaThe reaction mixture was cooled
3. 3
   FiltraciónThe solid was filtered off with suction
4. 4
   Lavadowashed with water
5. 5
   FiltraciónThe crystallizate was filtered
6. 6
   Lavadowashed with ethanol
7. 7
   Otrodried under reduced pressure

Procedimiento

16.8 g (0.7 mol) of sodium hydride were introduced in portions with stirring into a suspension of 99.6 g (0.6 mol) of 3-methylxanthine in 1.5 l of dimethylformamide. After evolution of hydrogen had ended, the mixture was heated to 100° C., treated dropwise with 76 g (0.6 mol) of benzyl chloride and heated at 120° C. for a further 6 hours. The reaction mixture was cooled and cautiously poured into 3 l of water. The solid was filtered off with suction and washed with water, the filter residue was taken up in ethanol and the solution was stirred at room temperature for one hour. The crystallizate was filtered, washed with ethanol and dried under reduced pressure.

Fuente