Reacción #2076706

Ecuación de reacción

THF

2-(3′-nitro-biphenyl-3-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine

→

title compound

Rendimiento 85.2%

3′-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-biphenyl-3-ylamine

Rendimiento 85.2%

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe catalyst was removed by filtration
2. 2
   Otrothe obtained solution evaporated
3. 3
   OtroThe crude product was further purified by crystallization from diethyl ether/hexane

Procedimiento

To a stirred suspension of 2-(3′-nitro-biphenyl-3-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (1.6 g, 3.27 mmol) in MeOH (40 mL) was added at room temperature Pd—C (10%, 0.16 g) and THF (40 mL). The mixture was stirred at room temperature under H2 atmosphere for 2 h, the catalyst was removed by filtration and the obtained solution evaporated. The crude product was further purified by crystallization from diethyl ether/hexane to yield the title compound as an off-white solid (1.28 g, 85%). MS (ISP) 460.2 [(M+H)+]; mp 156.5° C.

Fuente