Reacción #2075010

Ecuación de reacción

3-bromo-dihydrofuran-2(3H)-one

(4-mercaptophenyl)methanol

triethylamine

→

product

Rendimiento 73.3%

3-(4-(hydroxymethyl)phenylthio)dihydrofuran-2(3H)-one

Rendimiento 73.3%

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed sequentially with saturated NH4Cl and NaCl solutions
2. 2
   SecadoThe organics were dried over MgSO4
3. 3
   Concentraciónconcentrated under reduced pressure

Procedimiento

3-bromo-dihydrofuran-2(3H)-one (2.35 g, 14.3 mmol) was added to a solution of (4-mercaptophenyl)methanol (2.00 g, 14.0 mmol) and triethylamine (2.4 mmol, 17 mmol). The reaction was stirred at room temperature overnight, then was diluted with CH2Cl2 and washed sequentially with saturated NH4Cl and NaCl solutions. The organics were dried over MgSO4 and concentrated under reduced pressure to provide the product as a viscous oil (2.3 g, 72%).

Fuente