Reacción #2069955

Ecuación de reacción

ammonium formate

compound

1-(3-Methoxyphenyl)-2-nitro-1-ethanol

→

title compound

Rendimiento 72.6%

2-Amino-1-(3-methoxyphenyl)-1-ethanol

Rendimiento 72.6%

Disolventes

tetrahydrofuran

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe catalyst was removed by filtration
2. 2
   workup.ADDITIONthe filtrate was diluted with ether
3. 3
   Otroprecipitates
4. 4
   Otrowere removed by filtration
5. 5
   Concentraciónthe obtained filtrate was concentrated

Procedimiento

Palladium-carbon (10%, 0.64 g) and ammonium formate (4.8 g) were added to a mixed solution of the compound of Example B142 (3.0 g, 15 mmol) in tetrahydrofuran (43 ml) and methanol (43 ml), and this mixture was stirred at room temperature for 18 hours. The catalyst was removed by filtration, the filtrate was diluted with ether, precipitates were removed by filtration, and the obtained filtrate was concentrated to give the title compound (1.82 g). This compound was used in the following reaction without further purification.

Fuente