Reacción #2069952

Ecuación de reacción

water

potassium carbonate

t-butyl bromide

4-pentynoic acid

→

title compound

t-Butyl 4-pentynoate

Disolventes

N,N-dimethylacetamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe reaction mixture was extracted with ethyl acetate
2. 2
   Lavadowashed with water
3. 3
   Secadodried over anhydrous magnesium chloride
4. 4
   Filtraciónfiltered through silica gel
5. 5
   ConcentraciónThe filtrate was concentrated under reduced pressure

Procedimiento

Benzyltriethylammonium chloride (5.92 g), potassium carbonate (93.4 g), and t-butyl bromide (143 ml) were added to a solution of 4-pentynoic acid (2550 mg) in N,N-dimethylacetamide (230 ml), and this reaction mixture was stirred at 55° C. for 24 hours. After water was added, the reaction mixture was extracted with ethyl acetate, washed with water, dried over anhydrous magnesium chloride, and then filtered through silica gel. The filtrate was concentrated under reduced pressure to give the title compound (2.10 g). This compound was used in the following reaction without further purification.

Fuente