Reacción #2069939

Ecuación de reacción

3-(2-naphthalen-2-yl-propionylamino)-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester

TFA DCM

→

title compound

Rendimiento 101.6%

3-(2-Naphthalen-2-yl-propionylamino)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester

Rendimiento 101.6%

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroevaporated to dryness
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in DCM
3. 3
   Lavadothe solution was washed with brine
4. 4
   workup.ADDITIONtreated with NaHCO3 aq. The obtained precipitate
5. 5
   Filtraciónwas filtered
6. 6
   Lavadowashed with water and DCM
7. 7
   Otrodried under vacuum

Procedimiento

2.5 g (5.2 mmol) of 3-(2-naphthalen-2-yl-propionylamino)-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester in 15 ml DCM was treated with 16 ml of (1:1) TFA/DCM. The reaction mixture was stirred for 30 min. and evaporated to dryness. The resulting residue was dissolved in DCM and the solution was washed with brine and then treated with NaHCO3 aq. The obtained precipitate was filtered, washed with water and DCM, and then dried under vacuum to give 2.0 g (quantitative yield) of the title compound.

Fuente