Reacción #2069926

Ecuación de reacción

N-Acetyl-N,N-di(4-isopropylphenyl)amine

→

N,N-Di-(4-isopropylphenyl)amine

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONThe ethanolic solution is poured into dist
2. 2
   Filtraciónwater, and the brownish precipitate is filtered off with suction
3. 3
   workup.DISSOLUTIONdissolved in dichloromethane
4. 4
   Secadodried with sodium sulphate
5. 5
   ConcentraciónThe solution is concentrated
6. 6
   Otrochromatographed through a short silica gel column with 50% dichloromethane in hexane
7. 7
   ConcentraciónThe product fractions are concentrated to dryness
8. 8
   Otrothe product is dried under reduced pressure

Procedimiento

N-Acetyl-N,N-di(4-isopropylphenyl)amine (5.4 g, 18.4 mmol) are heated to reflux in 100 ml of 20% aqueous ethanol. The reaction is monitored by thin-layer chromatography. After 30 h, no reactant is any longer detectable in the TLC. The ethanolic solution is poured into dist. water, and the brownish precipitate is filtered off with suction, dissolved in dichloromethane and dried with sodium sulphate. The solution is concentrated and chromatographed through a short silica gel column with 50% dichloromethane in hexane. The product fractions are concentrated to dryness and the product is dried under reduced pressure.

Fuente